Consult a health care practitioner if negative menopausal or menarche symptoms persist and/or worsen. Consult a health care practitioner prior to use if you are taking hormone-containing medications such as progesterone preparations, oral contraceptives or hormone replacement therapy (HRT). Do not use if you are pregnant or breastfeeding, have hormone sensitive conditions such as uterine, endometrial, breast, or ovarian cancer as well as endometriosis and uterine fibroids. Do not use if you have a protein S deficiency as wild yam may increase the risk of thrombosis.