Below is a list of the active ingredients in Selah Botanicals Wild Yam Plus Tincture with their respective benefits as set out in published medical studies.
Wild Yam
Diosgenin in wild yamroot (DOI) was found to stimulate estradiol biosynthesis in rat ovarian granulosa cells; induce estradiol and progesterone secretion in 16- to 18-month-old female Sprague Dawley rats by upregulating expressions of follicle stimulating hormone receptor and ovarian aromatase; counteract the progression of osteoporosis and augment bone mineral density; and improve cognitive functioning by upregulating protein expressions of brain-derived neurotrophic factor and TrkB receptors in the prefrontal cortex.
Furthermore, DOI did not stimulate the proliferation of breast cancer and ovarian cancer cells, which suggest it could be a more efficacious and safer alternative to HRT.
Diosgenin-Rich Yam Extract Enhances Cognitive Function: A Placebo-Controlled,Randomized, Double-Blind, Crossover Study of Healthy Adults 2017 Nutrients
Diosgenin Exerts Analgesic Effects by Antagonizing the Selective Inhibition of Transient Receptor Potential Vanilloid 1in a Mouse Model of Neuropathic Pain International Journal of Molecular Sciences 2022
Diosgenin improves functional recovery from sciatic crushed nerve injury in rats 2018 Journal of Exercise Rehabilitation
Chasteberry
Electronic Physician January 2017.
Systematic Review of Premenstrual, Postmenstrual and Infertility Disorders of Vitex Agnus Castus
https://pmc.ncbi.nlm.nih.gov/articles/PMC5308513/
Introduction: Vitex agnus-castus, also called vitex is aboriginal to the Mediterranean region, with long leaves, tender stem, flowers and ripening seeds. The aim of this study was to overview premenstrual, postmenstrual and infertility disorder of Vitex agnus-castus.
Methods: This review article was carried out by searching studies in PubMed, Medline, Web of Science, and lranMedex databases. The initial search strategy identified about 87 references. In this study, 43 studies were accepted for further screening, and met all our inclusion criteria {in English, full text, therapeutic effects of Vitex agnus-castus and dated mainly from the year 2009 to 2016). The search terms were Vitex agnus-castus, premenstrual, postmenstrual, infertility disorder properties and pharmacological effects.
Result: Vitex agnus-castus was shown to contribute to the treatment of premenstrual syndrome (PMS). Moreover, the result of the present study showed that this valuable plant is helpful in alleviation of pain resulting from postmenstrual disease. Furthermore, it was found that Vitex agnus-castus is beneficial in infertility disorder.